The Atypical HUS Foundation

When I was reading the slides from the conference I came across the above. I don't really know much about this. On the European Medicines Agency I found out that the orphan designation was granted in 2007 for the development of Factor H and it is thought that the supplementation of purified factor H would alleviate the disease. It also says that the evaluation of the effects of complement factor H in experimental models is ongoing.
It was in 2007...would anybody know whether there's been any progress with this? Could this actually mean that it would have the potential to restore a normal capacity to regulate complement activity. I would be grateful for any information.

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Comment by Cheryl Biermann on November 8, 2009 at 10:30pm
Sylwia, good luck, it's all highly secretive until someone has a major break through and then publishes something.
Comment by Sylwia Antkowiak on November 8, 2009 at 1:00pm
Thank you Cheryl for all the info, I will try to obtain the up to date info on this.

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Did you know...

CFH (Serum Complement Factor H) is a regulatory protein. The secreted protein product of CFH consists of 20 repetitive units named "short consensus repeats" or SCRs (each approximately 60 amino acids). In patients with aHUS the last 5 "pearls" in the twenty pearl strand protein, SCR16 - SCR20, should bind to protect cells but do not- they are defective in one or more of the last 5 SCR locations. If they cannot bind or stick to the kidney to protect that tissue, the platelets clump into clots that affect the glomeruli of the kidney -potentially causing acute renal failure.
  
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It is estimated that there are about 2 cases of aHUS in the U.S. per 1,000,000 of population, and about 60% of aHUS patients are diagnosed as children. The condition is potentially life threatening, and either can be chronic or can recur at intervals.
  
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