The Foundation for Children with Atypical HUS

Hello all, I am wondering if anyone on this site has both CFH and FH ANTIBODIES? If you do or you know of anyone that does can you please contact me. It's been awhile for me being on here because we…

Hello all, I am wondering if anyone on this site has both CFH and FH ANTIBODIES? If you do or you know of anyone that does can you please contact me. It's been awhile for me being on here because we have been in and out of the hospital tring to get it under control. Finally after everthing else not working setup 2 a week plasma exchange. I also need to find out more or at least other input on the soliris. Well talk to you soon.

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Comment by Grace on October 20, 2010 at 9:22pm
As far as I know, CFH="Complement Factor H" is synonymous with FH="Factor H", so it would be just one kind of antibody. I'm sorry I can't help you more. I hope you get what you need.

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The Foundation for Children with Atypical HUS encourages patients and investigators to share information and explore options/resources as we work together to gain insight into this rare complement disorder. By increasing contact opportunities with researchers and medical personnel interested in helping the aHUS community, our stories foster a better understanding of atypical hemolytic uremic syndrome.

Sharing information, inspiration and support for one another, we seek to gather together people and knowledge as we strive to improve the lives of patients and families dealing with a diagnosis of aHUS.


NEW DIAGNOSIS OF aHUS?
Be proactive! Get the medical basics of aHUS, what lab values to monitor, and areas of concern...check out the "aHUS Bootcamp" and "About aHUS" tabs at the top of this page!
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Did you know...

CFH (Serum Complement Factor H) is a regulatory protein. The secreted protein product of CFH consists of 20 repetitive units named "short consensus repeats" or SCRs (each approximately 60 amino acids). In patients with aHUS the last 5 "pearls" in the twenty pearl strand protein, SCR16 - SCR20, should bind to protect cells but do not- they are defective in one or more of the last 5 SCR locations. If they cannot bind or stick to the kidney to protect that tissue, the platelets clump into clots that affect the glomeruli of the kidney -potentially causing acute renal failure.
  
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It is estimated that there are about 300 cases of aHUS in the U.S., and it is most common with young children. The condition is life threatening and either can be chronic or can recur at intervals.
  
more factoids...

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