The Atypical HUS Foundation

MRI with contrast, (Gadolinium) and Renal insufficiency

Did you know, a renal patient should NOT receive an MRI with contrast? There are many reasons for receiving an MRI, those of you with seizure complications may have more reason for an MRI than others. The agent Gadolinium a non-radioactive agent that allows a clearer picture for doctors has also been found to cause Nephrogenic Systemic Fibrosis or Nephrogenic Fribrosing Dermopathy in people with renal insufficiency. This is a man-made disease caused by the renal patient's inability to rid the contrast from the body. The determination of this man-made disease was made in 1997. It is debilitating and sometimes fatal condition. It causes discoloration and thickening of the skin and connective tissues which inhibits movement which may result in broken bones, muscle weakness and scarring of the internal organs. Liver patients with any degree of renal insuffieciecy should also avoid MRIs using Gadollinium.

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Comment by Cheryl Biermann on November 14, 2009 at 9:36pm
Our doctors are won't even allow contrast on dialysis days, no one is sure if all of it can be dialyzed out. Glad to see your doctors are on top of this, Jessica.
Comment by Jessica Olivia Frysz on November 13, 2009 at 9:51am
Dialysis patients are even more at risk of this, because some of us can't get rid of it at all. Why, when doctors ask for contrast, we have to do it on a dialysis day, so that we can get it dialyzed out of our systems. Most of the time for me though, doctors try to get radiology studies without contrast.
Comment by Linda Burke on November 12, 2009 at 1:14pm
Wow - such important info for us all to know -thanks for adding it, Cheryl!


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The Atypical HUS Foundation encourages patients and investigators to share information and explore options/resources as we work together to gain insight into this rare complement disorder. By increasing contact opportunities with researchers and medical personnel interested in helping the aHUS community, our stories foster a better understanding of atypical hemolytic uremic syndrome.

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Did you know...

CFH (Serum Complement Factor H) is a regulatory protein. The secreted protein product of CFH consists of 20 repetitive units named "short consensus repeats" or SCRs (each approximately 60 amino acids). In patients with aHUS the last 5 "pearls" in the twenty pearl strand protein, SCR16 - SCR20, should bind to protect cells but do not- they are defective in one or more of the last 5 SCR locations. If they cannot bind or stick to the kidney to protect that tissue, the platelets clump into clots that affect the glomeruli of the kidney -potentially causing acute renal failure.
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It is estimated that there are about 2 cases of aHUS in the U.S. per 1,000,000 of population, and about 60% of aHUS patients are diagnosed as children. The condition is potentially life threatening, and either can be chronic or can recur at intervals.
more factoids...

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